banner
News center
Rich expertise and next-generation tools

CuFe2O4@SiO2@L

Dec 13, 2023

Scientific Reports volume 13, Article number: 8675 (2023) Cite this article

3251 Accesses

5 Altmetric

Metrics details

A novel magnetic heterogeneous catalyst was synthesized through the immobilization of copper ions onto the l-arginine functionalized CuFe2O4@SiO2. The prepared catalyst was characterized by Fourier Transform Infrared (FT-IR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), and Energy Dispersive X-Ray spectroscopy (EDX). The resulting catalyst was used in the ultrasonic-assisted synthesis of 1,2,3-triazoles via a one-pot three-component reaction of alkynes, alkyl halides, and sodium azides under green conditions within a short time. The catalyst reusability was investigated after five cycles and no significant loss of activity was observed.

Minimizing the generation of hazardous substances is an important obligation of green chemistry. Green catalytic processes, which include the use of non-toxic solvents (water, EtOH, etc.), reusable, efficient catalysts, and new synthetic route can pleasantly follow the principles of green chemistry1,2,3. Recently, sonochemistry has turned into an attractive synthetic technique in a green manner4. It contains many features, such as reducing hazardous chemicals, solvents, and energy consumption. The ultrasound mechanism is related to spontaneous creation, growth, and collapse of bubbles formed during the acoustic cavitation process, which can accelerate the reaction rate5. The release of a considerable amount of heat prepares the required energy for the reaction to driving forward. These unusual properties justify its widely uses in the synthesis of organic and inorganic materials6.

Triazole systems as important five-membered ring structures composed of three nitrogen atoms are found in many pharmaceutical and agrochemical structures. They possess wide biological activities such as: anti-inflammatory7, antimicrobial8, antimalarial9, antiviral10, and anticancer11 activities. These versatile scaffolds have been specified in numerous clinically used drugs emphasizing their importance. Due to the importance of these heterocyclic structures, they can be readily synthesized in click reaction. The Huisgen reaction is the first example of to click reaction in which the 1,3-dipolar cycloaddition of azides to alkynes catalyzes by copper and forms the five-membered heterocycles12. This concerted [3 + 2] thermally cycloaddition cannot be proceeded in the absence of catalyst. Metal-based catalysts were employed over the years to defeat this deficiency13,14.

The homogeneous catalytic systems like copper nanoparticles15, copper nanoclusterss16, and in-situ reduction of Cu(II) salts to Cu(I) salts17, have some disadvantages related to the recovering and reusing ability for successive reaction cycles and the presence of metal contamination in the end product. The utilization of heterogeneous catalysts can be a promising solution overcoming this problem. The heterogeneous catalysts should compete with each other in economical and environmentally friendly subjects. There have been many surfaces reported for copper immobilizing so far, such as: CuO hollow nanosphere18, shillajit19, charcoal20, SBA-1521 and so on which often suffer from separating and leakage problems. So, using magnetic supporters can be a good choice to attain easy separation, thermal stability, and low toxicity properties.

But the major disadvantages associated with these homogeneous copper catalysts are the difficulties to recover and reuse for successive reaction cycles and the possibility of metal contamination with the end product. To overcome these serious issues, various solid-supports like zeolites [53], polymers [54,55], carbon [44], silica [56] etc. have been employed to synthesize the corresponding heterogeneous copper catalysts by immobilizing the active metal ions onto the solid supports.

In continuation of our work on the synthesis of heterocyclic structures22,23,24, we reported the synthesis of a new efficient magnetite-base catalytic system, CuFe2O4@SiO2@l-arginine@Cu, along with its application in an approach to 1,2,3-triazole derivatives. The procedure uses phenylacetylene as an alkyne, sodium azide, and various alkyl halides as the other component to form triazoles. The reaction was done in ultrasonic-assisted green conditions and the catalyst removed with an external magnet (Fig. 1). The reaction yields were excellent and the prepared catalyst has a good efficiency even after five cycles.

CuFe2O4@SiO2@l-arginine@Cu (I) as an appropriate catalyst for click reaction. (Created with BioRender.com).

All the reactants were purchased from Merck Chemical Company and Aldrich and used without further purification. Fourier transform infrared (FT-IR) spectra were recorded as KBr pellets using a Bruker VRTEX 70 model FT-IR spectrophotometer. Powder X-ray diffraction (XRD) patterns were collected with a Rigaku-Dmax 2500 diffractometer with nickel filtered Cu Kα radiation (λ = 1.5418 Å, 40 kV). Supermagnetic properties of the catalyst were measured with a vibrating sample magnetometer at room temperature.

CuFe2O4 was readily synthesized using a chemical co-precipitation method previously reported25, followed by a SiO2-coating procedure26. Briefly, 2.00 g of the obtained CuFe2O4 was dispersed in a mixture of 100 mL of ethanol, 40 mL of deionized water and 6 mL of concentrated aqueous ammonia solution, followed by the addition of 4 mL tetraethylorthosilicate (TEOS). This solution was stirred mechanically at room temperature overnight. Then the product, CuFe2O4@SiO2, was separated using an external magnet, washed with deionized water and ethanol three times, and dried at room temperature.

In the second step, CuFe2O4@SiO2@l-arginine nanocatalyst was synthesized using the following procedure. An amount of 1 g of CuFe2O4@SiO2 was suspended in deionized water (20 mL) and became highly dispersed via sonication. Then, 2 g of l-arginine was added and the mixture was stirred at 90 °C for 15 h. CuFe2O4@SiO2@l-arginine nanoparticles were separated from the aqueous solution by applying an external magnet, washed with distilled water and then dried in an oven. The whole synthesis was done under an inert atmosphere. In the last step, incorporation of copper onto the CuFe2O4@SiO2@l-arginine nanocomposite was carried out by mixing the CuFe2O4@SiO2@l-arginine (1 g) and CuI (0.5 g) in absolute ethanol (50 mL). The mixture was refluxed for 24 h. Cu(I) ions were adsorbed onto the magnetic nanocarrier. Finally, the synthesized CuFe2O4@SiO2@l-arginine@Cu(I) nanocomposite as a brown powder was separated from the suspension using magnetic decantation, washed with absolute ethanol and dried under vacuum at room temperature.

A mixture of CuFe2O4@SiO2@l-arginine@Cu(I) (1 mol% of Cu), benzyl halide (1.0 mmol), phenylacetylene derivatives (1.2 mmol), and NaN3 (1.2 mmol) in a 1:1 mixture of H2O:EtOH (3 ml) was irradiated under sonication for an appropriate time (Tables S1 and S2). After completion of the reaction monitored by TLC, the catalyst was separated with an external magnet and the solvents were removed under vacuum evaporator and the product was further purified by EtOH/water system.

The synthetic pathway of CuFe2O4@SiO2@l-arginine@Cu(I) is illustrated in Fig. 2. CuFe2O4 NPs were prepared through a co-precipitation method by dissolving salts into distilled water, followed by precipitation with NH4OH. Afterward, TEOS was hydrolyzed to form silica oligomers, which were coated on the surface of CuFe2O4 nanoparticles to obtain CuFe2O4@SiO2 nanoparticles. CuFe2O4@SiO2@l-arginine was obtained by nucleophilic addition of arginine to as-prepared magnetic nanoparticles. Subsequently, the copper was linked to the nitrogen groups of arginine.

Schematic representation of the catalyst synthesis procedures.

The structure, morphology and magnetic properties of the prepared catalyst were entirely characterized by analytical techniques. The FT-IR spectra of the CuFe2O4@SiO2@l-arginine@Cu, CuFe2O4@SiO2, and CuFe2O4 are compared in Fig. S1 (see supporting information). The FTIR spectrum of CuFe2O4 indicates the characteristic bands of metal–O at 645 cm−1, 579 cm−1 and 479 cm−127 and the absorption peak at 3430 cm−1 is ascribed to the OH stretching vibration, indicating the presence of hydrogen bonded hydroxyl groups on the surface of CuFe2O4 nanoparticles35 . The sharp bands at 1072 cm−1 and 816 cm−1 were assigned to the asymmetric and symmetric stretching vibrations of Si–O–Si bonding respectively. In Fig. S1c, the absorption peak at 3426 cm−1 was assigned to the O–H stretching vibrations which shifted from 3426 to 3276 cm-1 in CuFe2O4@SiO2@l-arginine with a net reduction in the intensity indicating the involvement of arginine in the synthesis of composite. Moreover, C=N stretching vibrations in the FTIR spectrum of the final catalyst appear at 1629 cm−1 which is lower than C=N stretching vibrations in the FTIR spectrum of CuFe2O4@SiO2@l-Arginine due to the formation of metal-ligand bonds.

The morphology and the structure of the CuFe2O4@SiO2@l-arginine@Cu(I) was characterized by SEM and TEM analysis (Fig. 3a–f). The almost uniform distribution and spherical structure of the catalyst is clearly observable in SEM images. The core-shell structure of the magnetic particles was proofed via TEM analysis with the black centers and the brightest areas as CuFe2O4 cores and SiO2 shells, respectively.

SEM images of (a, b) CuFe2O4@SiO2@l-arginine-Cu (I), (c, d) Reused catalyst after 4 runs, and (e, f) TEM images of CuFe2O4@SiO2@l-arginine-Cu (I).

The Brunauer–Emmett–Teller (BET) method was applied to calculate the surface area and pore diameter of the prepared catalyst. According to the BET analysis results presented in Fig. S2 (See supporting information), the surface area and average pore diameter are 33.65 m2/g and 17.59 nm for CuFe2O4@SiO2@L-arginine@Cu(I) catalyst.

To determine the oxidation states of Cu in the prepared catalyst, XPS analysis was performed. The XPS analysis of the CuFe2O4@SiO2@L-arginine@Cu(I) nanoparticles (Fig. S3, supporting information) revealed the characteristics peaks for C 1 s (284.88), O 1 s (530.39), Fe 2p (710.89) and Cu 2p (933.01). The Cu2p3/2 peaks located at 933.0 eV was attribute to Cu1.

The EDS analysis results confirmed the presence of carbon, oxygen, nitrogen, copper, iron, and Si elements in the catalyst (ratios of 9.0: 27.6: 0.4: 6.4: 23.9: 32.8 wt%, respectively) shown in Fig. 4 and inset. It also confirms the immobilization of Cu on CuFe2O4@SiO2@l-arginine was achieved successfully. Moreover, the accurate amount of copper in the final catalyst composition determined via ICP analysis was 9.14%.

Energy dispersive X-ray analysis (EDX) of CuFe2O4@SiO2@l-arginine@Cu (I) and b) elemental mapping of C (orange); N (purple), O (blue), Fe (red), Si (green), and Cu (yellow) atoms for CuFe2O4@SiO2@l-arginine@Cu (I).

The magnetic properties of CuFe2O4, CuFe2O4@SiO2 and CuFe2O4@SiO2@l-arginine@Cu (I) were studied using VSM analysis at ambient temperature with the magnetic field sweeping from − 10,000 to + 10,000 Oe, and the magnetization cycles are shown in Fig. S4 (see supporting information). Obviously, the particles showed zero remanent magnetization which is the reason for their superparamagnetic behavior. Superparamagnetic nanoparticles would not aggregate magnetically due to the lack of net magnetization in the absence of an external field27,28. Magnetic hysteresis loop measurements revealed the maximum saturation magnetization value of CuFe2O4@SiO2@l-arginine@Cu (I) was less than CuFe2O4 (58.2 emus. g-1) which proved the incorporation of arginine and copper on the surface of CuFe2O4.

The crystal structure of the prepared samples was examined using X-ray diffraction pattern (XRD) shown in Fig. S5 (See supporting information). the XRD pattern of CuFe2O4 revealed characteristic diffraction peaks at 2θ = 30.206°, 35.579°, 43.361°, 50.475, 53.678°, 57.146°, 62.788°, 74.296° corresponding to the (220), (311), (400), (107), (422), (511), (440), and (533) reflection crystal plans of CuFe2O4 respectively (JCPDS card no. 25-0283) which have been reported in the literature29. The slightly broad diffraction peak at 2θ value 20–30° was attributed to the amorphous silica indicated the formation of SiO2 shell does not change the crystal form of CuFe2O4 (JCPDS card no.00-002-0278). The XRD pattern of CuFe2O4@SiO2@l-arginine@Cu(I) revealed a sharp peak at 28.438 attributed to CuI. Moreover, the XRD pattern of reused CuFe2O4@SiO2@l-arginine@Cu(I) showed that the crystalline structure of catalyst remained unchanged after several runs. (The reference card numbers were collected from the X'pert HighScore Plus version 1.0d software developed by the PANalytical B.V.)

Thermal behavior of the prepared catalyst was analyzed using TGA and DTG under Ar atmosphere at a temperature varying from 50 to 800 °C and the plotted curve shown in Fig. S6 (See supporting information). The TGA thermogram of CuFe2O4@SiO2@L-arginine@Cu(I) shows two stage weight loss over the temperature range of TG analysis. The first stage, including a low amount of weight loss (6%) at T ~ 110 °C, resulted from the release of both the physiosorbed and chemisorbed water, the second stage at about 290 °C to nearly 460 °C is attributed to the decomposition of the organic moiety in the nanocomposite including a weight loss (45%).

The catalytic behavior of CuFe2O4@SiO2@l-arginine-Cu(I) was investigated for the synthesis of triazole derivatives via a three-component reaction between sodium azide, phenylacetylene, and benzyl halide under different conditions. To find the optimal reaction conditions, various factors such as catalyst loading, solvent, time and reaction temperature were scrutinized in a model reaction including phenylacetylene, benzyl bromide, and sodium azide presented in Table S1 (see supporting information).

For further optimization, the type of catalyst was also investigated and tabulated in Table S2 (See supporting information). The results revealed the high performance of CuFe2O4@SiO2@l-arginine-Cu(I) due to synergistic effects and improved number of active sites on the surface. The conversion of 87% was reached for 15 mg catalyst loading under ultrasonic irradiation. Obviously, the increase in catalyst loading was not favorable. On the other hand, with an amount of catalyst of 30 mg, the yield did not change significantly compared to 15 mg.

To generalize the optimum conditions, different 1,2,3-triazole derivatives from 4a–j were prepared through a one-pot reaction of acetylene derivatives 1, sodium azide 2 and benzyl halide derivatives in the presence of CuFe2O4@SiO2@l-arginine@Cu(I) (Fig. 5). The results are summarized in Table 1. As expected, the presence of electron-withdrawing groups on benzyl halide can enhance the rate and yield of the reaction. On the other hand, the reaction with benzyl bromide is much better than benzyl chloride. It can perhaps be because of the fact that -Br is a good leaving group in the substation reaction of azide anion.

Schematic representation of the CuFe2O4@SiO2@l-arginine@Cu(I) in one-pot synthesis of 1,2,3 triazoles (4a-l).

In addition, for better characterization of the products the 1HNMR spectra of the samples 4 h and 4i have been represented in Figs. S8 and S9 respectively (see supporting information).

Additionally, the efficiency of the catalyst was shown via the turnover number (TON) and turnover frequency (TOF) of the catalyst and provided in Table 1. As can be seen, the obtained values of TOF are between 2 and 5.6 S-1, which is very valid for relevant industrial applications, for which the TOF is in the range10−2 and 102 S−130.

The proposed mechanism of the model reaction for triazole derivatives synthesis is mentioned in Fig. 6. In the first step the bifunctional catalyst forms copper acetylide (A). On the other hand, the organic azide was synthesized in-situ by the reaction of aryl halide with NaN3. Then the coordination of the organic azide to the copper acetylide was occurred and by the Huisgen 1, 3-dipolar cycloaddition reaction of (A) and (B) the final desired 1,2,3 triazole (C) obtained.

Proposed catalytic mechanism of CuFe2O4@SiO2@l-arginine@Cu(I).

The hot filtration test was carried out to investigate the heterogeneous nature of the CuFe2O4@SiO2@l-arginine@Cu(I) in the synthesis of 1,2,3 triazole. At first, the model reaction was performed under the optimized reaction condition. After 10 min (43% conversion), the catalyst was removed from the reaction by an external magnet and also simple filtration. The reaction was then allowed to proceed without catalyst for 30 min. The results showed that the reaction did not progress in the absence of CuFe2O4@SiO2@l-arginine@Cu(I), thus proving the heterogeneity of the catalyst and the non-leaching of copper in the solution.

The easy separation of CuFe2O4@SiO2@l-arginine@Cu(I) as a heterogeneous catalyst was mentioned before. In this regard, the recyclability of the nanocatalyst in the model reaction was investigated. At the end of the reaction, CuFe2O4@SiO2@l-arginine@Cu(I) was collected by an external magnetic field and washed with ethanol and water. The dried magnetic nanocatalyst was successively used for five times in the model reaction with a yield of 75%. According to the results displayed in Fig. S7 (see supporting information), there is no significant reduction in the catalytic efficiency of CuFe2O4@SiO2@l-arginine@Cu(I). Furthermore, according to the FESEM images shown in Fig. 3c,d there is no structural changes in catalyst after 5 times recycling. FTIR spectra of the fresh and recycled catalyst were shown in Fig. S1 (see Supporting Information). It is clear that the used catalyst has not undergone any structural changes.

In order to determine the catalytic efficacy of the prepared CuFe2O4@SiO2@l-arginine@Cu(I) in the preparation of 1,2,3 triazoles, the present work was compared with the previous reports. As it is obvious, the prepared catalyst has several advantages in the time of reaction time, solvent, and yield which are presented in Table 2.

In summary, we devised a novel collagen-coated superparamagnetic organic-inorganic hybrid catalyst, CuFe2O4@SiO2@l-arginine@Cu(I), which exhibited radically enhanced catalytic activity in the synthesis of a wide range of substituted 1,2,3 triazole derivatives through a one-pot atom economical Huisgen 1, 3-dipolar cycloaddition reaction of acetylene derivatives, sodium azide, and benzyl halide under ultrasonic irradiation. This heterogeneous catalyst efficiency is achieved in several aspects, such as high product yields and reactivity in a green manner, stability, recyclability, and high reaction rate. Furthermore, the easy separation and removal from the reaction make this catalyst a good choice for use in other synthetic applications. These results affirmed that the novel CuFe2O4@SiO2@l-arginine@Cu(I) can be used as a versatile catalyst for promoting chemical reactions.

All data generated or analysed during this study are included in this published article [and its supplementary information files].

Kerton, F. M. & Marriott, R. Alternative Solvents for Green Chemistry (Royal Society of Chemistry, 2013).

Book Google Scholar

Kirchhoff, M. M. Promoting sustainability through green chemistry. Resour. Conserv. Recycl. 44, 237–243 (2005).

Article Google Scholar

Anastas, P. T. Green chemistry and the role of analytical methodology development. Crit. Rev. Anal. Chem. 29, 167–175 (1999).

Article CAS Google Scholar

Kurniawan, Y. S., Priyangga, K. T. A., Krisbiantoro, P. A. & Imawan, A. C. Green chemistry influences in organic synthesis: A review. J. Multidiscip. Appl. Nat. Sci. 1(1), 1–12. https://doi.org/10.47352/jmans.v1i1.2 (2021).

Article Google Scholar

McKenzie, T. G., Karimi, F., Ashokkumar, M. & Qiao, G. G. Ultrasound and sonochemistry for radical polymerization: Sound synthesis. Chem. Eur. J. 25, 5372–5388 (2019).

Article CAS PubMed Google Scholar

Pourian, E., Javanshir, S., Dolatkhah, Z., Molaei, S. & Maleki, A. Ultrasonic-assisted preparation, characterization, and use of novel biocompatible core/shell Fe3O4@ GA@ isinglass in the synthesis of 1, 4-dihydropyridine and 4 H-pyran derivatives. ACS Omega 3, 5012–5020 (2018).

Article CAS PubMed PubMed Central Google Scholar

Zhang, T.-Y. et al. New ursolic acid derivatives bearing 1, 2, 3-triazole moieties: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Mol. Divers. 26, 1129–1139 (2022).

Article CAS PubMed Google Scholar

Strzelecka, M. & Świątek, P. 1, 2, 4-Triazoles as important antibacterial agents. Pharmaceuticals 14, 224 (2021).

Article CAS PubMed PubMed Central Google Scholar

Eya’ane Meva, F. et al. Anti-inflammation and antimalarial profile of 5-pyridin-2-yl-1H-[1, 2, 4] triazole-3-carboxylic acid ethyl ester as a low molecular intermediate for hybrid drug synthesis. Res. Chem. Intermed. 48, 885–898 (2022).

Article Google Scholar

Ji, K. et al. Design, synthesis, and anti-influenza A virus activity evaluation of novel indole containing derivatives of triazole. Bioorg. Med. Chem. Lett. 64, 128681 (2022).

Article CAS PubMed Google Scholar

Alam, M. M. 1, 2, 3-Triazole hybrids as anticancer agents: A review. Arch. Pharm. 355, 2100158 (2022).

Article CAS Google Scholar

Moghaddam, F. M. & Ayati, S. E. Copper immobilized onto a triazole functionalized magnetic nanoparticle: A robust magnetically recoverable catalyst for "click" reactions. RSC Adv. 5, 3894–3902. https://doi.org/10.1039/C4RA13330G (2015).

Article ADS CAS Google Scholar

Basu, P. et al. Silver nanoparticles supported over Al2O3@ Fe2O3 core-shell nanoparticles as an efficient catalyst for one-pot synthesis of 1, 2, 3-triazoles and acylation of benzyl alcohol. Mol. Catal. 439, 31–40 (2017).

Article CAS Google Scholar

Elavarasan, S., Bhaumik, A. & Sasidharan, M. An efficient mesoporous Cu-organic nanorod for Friedländer synthesis of quinoline and click reactions. ChemCatChem 11, 4340–4350 (2019).

Article CAS Google Scholar

Pathigoolla, A., Pola, R. P. & Sureshan, K. M. A versatile solvent-free azide–alkyne click reaction catalyzed by in situ generated copper nanoparticles. Appl. Catal. A 453, 151–158 (2013).

Article CAS Google Scholar

Pachón, L. D., van Maarseveen, J. H. & Rothenberg, G. Click chemistry: Copper clusters catalyse the cycloaddition of azides with terminal alkynes. Adv. Synth. Catal. 347, 811–815 (2005).

Article Google Scholar

Bock, V. D., Hiemstra, H. & Van Maarseveen, J. H. CuI-catalyzed alkyne–azide "click" cycloadditions from a mechanistic and synthetic perspective. Eur. J. Org. Chem. 2006, 51–68 (2006).

Article Google Scholar

Kim, J. Y., Park, J. C., Kang, H., Song, H. & Park, K. H. CuO hollow nanostructures catalyze [3+ 2] cycloaddition of azides with terminal alkynes. Chem. Commun. 46, 439–441 (2010).

Article CAS Google Scholar

Norouzi, F. & Javanshir, S. Magnetic γFe2O3@ Sh@ Cu2O: An efficient solid-phase catalyst for reducing agent and base-free click synthesis of 1, 4-disubstituted-1, 2, 3-triazoles. BMC Chem. 14, 1–16 (2020).

Article PubMed PubMed Central Google Scholar

López-Ruiz, H. et al. Cuprous oxide on charcoal-catalyzed ligand-free synthesis of 1, 4-disubstituted 1, 2, 3-triazoles via click chemistry. Arkivoc 3, 139–164 (2013).

Google Scholar

Roy, S. et al. Cu (II)-anchored functionalized mesoporous SBA-15: An efficient and recyclable catalyst for the one-pot Click reaction in water. J. Mol. Catal. A Chem. 386, 78–85 (2014).

Article CAS Google Scholar

Azarnier, S. G., Esmkhani, M., Dolatkhah, Z. & Javanshir, S. Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis. Sci. Rep. 12, 1–11 (2022).

Article Google Scholar

Jafarzadeh, F., Dolatkhah, Z., Molaei, S. & Javanshir, S. CS@ Cu2O and magnetic Fe3O4@ SiO2-pAMBA-CS-Cu2O as heterogeneous catalysts for CuAAC click reaction. Arab. J. Chem. 15, 103838 (2022).

Article CAS Google Scholar

Nosrati, A., Amirnejat, S. & Javanshir, S. Preparation, antibacterial activity, and catalytic application of magnetic graphene oxide-fucoidan in the synthesis of 1, 4-dihydropyridines and polyhydroquinolines. ChemistryOpen 10, 1186–1196 (2021).

Article CAS PubMed PubMed Central Google Scholar

Zhu, M., Meng, D., Wang, C. & Diao, G. Facile fabrication of hierarchically porous CuFe2O4 nanospheres with enhanced capacitance property. ACS Appl. Mater. Interfaces. 5, 6030–6037 (2013).

Article CAS PubMed Google Scholar

Chen, S., Sun, Y., Li, X. & Song, H. N-acetyl-L-cysteine modified CuFe2O4@ SiO2 core-shell nanoparticles as chiral probes for recognition of chiral tyrosine. J. Solid State Chem. 280, 120994 (2019).

Article CAS Google Scholar

Sun, J. et al. Synthesis and characterization of biocompatible Fe3O4 nanoparticles. J. Biomed. Mater. Res. Part A 80, 333–341 (2007).

Article Google Scholar

Gao, J., Gu, H. & Xu, B. Multifunctional magnetic nanoparticles: Design, synthesis, and biomedical applications. Acc. Chem. Res. 42, 1097–1107 (2009).

Article CAS PubMed Google Scholar

Cahyana, A. H., Liandi, A. R., Yulizar, Y., Romdoni, Y. & Wendari, T. P. Green synthesis of CuFe2O4 nanoparticles mediated by Morus alba L. leaf extract: Crystal structure, grain morphology, particle size, magnetic and catalytic properties in Mannich reaction. Ceram. Int. 47, 21373–21380 (2021).

Article CAS Google Scholar

Hagen, J. Industrial Catalysis: A Practical Approach (John Wiley & Sons, 2015).

Book Google Scholar

Khalili, D. & Rezaee, M. Impregnated copper ferrite on mesoporous graphitic carbon nitride: An efficient and reusable catalyst for promoting ligand-free click synthesis of diverse 1, 2, 3-triazoles and tetrazoles. Appl. Organomet. Chem. 33, e5219 (2019).

Article CAS Google Scholar

Mohammadkhani, A. & Heydari, A. Nano-magnetic-iron Oxides@ choline acetate as a heterogeneous catalyst for the synthesis of 1, 2, 3-triazoles. Catal. Lett. 152, 1678–1691 (2022).

Article CAS Google Scholar

Shaabani, A., Afshari, R. & Hooshmand, S. E. Crosslinked chitosan nanoparticle-anchored magnetic multi-wall carbon nanotubes: A bio-nanoreactor with extremely high activity toward click-multi-component reactions. New J. Chem. 41, 8469–8481 (2017).

Article CAS Google Scholar

Bonyasi, R., Gholinejad, M., Saadati, F. & Nájera, C. Copper ferrite nanoparticle modified starch as a highly recoverable catalyst for room temperature click chemistry: Multicomponent synthesis of 1, 2, 3-triazoles in water. New J. Chem. 42, 3078–3086 (2018).

Article CAS Google Scholar

Chavan, P. V., Pandit, K. S., Desai, U. V., Kulkarni, M. A. & Wadgaonkar, P. P. Cellulose supported cuprous iodide nanoparticles (Cell-CuI NPs): A new heterogeneous and recyclable catalyst for the one pot synthesis of 1, 4-disubstituted–1, 2, 3-triazoles in water. RSC Adv. 4, 42137–42146 (2014).

Article ADS CAS Google Scholar

Luciani, L., Goff, E., Lanari, D., Santoro, S. & Vaccaro, L. Waste-minimised copper-catalysed azide–alkyne cycloaddition in Polarclean as a reusable and safe reaction medium. Green Chem. 20, 183–187 (2018).

Article CAS Google Scholar

Bahri-Laleh, N., Sadjadi, S., Heravi, M. M. & Malmir, M. CuI-functionalized halloysite nanoclay as an efficient heterogeneous catalyst for promoting click reactions: Combination of experimental and computational chemistry. Appl. Organomet. Chem. 32, e4283 (2018).

Article Google Scholar

Amini, M., Hajipour, E., Akbari, A. & Hwa Chae, K. Immobilization of copper nanoparticles on WO3 with enhanced catalytic activity for the synthesis of 1, 2, 3-triazoles. Appl. Organomet. Chem. 34, e5959 (2020).

Article CAS Google Scholar

Bahsis, L. et al. A reusable polymer-supported copper (I) catalyst for triazole click reaction on water: An experimental and computational study. Appl. Organomet. Chem. 33, e4669 (2019).

Article Google Scholar

Pazoki, F., Salamatmanesh, A., Bagheri, S. & Heydari, A. Synthesis and characterization of copper (I)-cysteine complex supported on magnetic layered double hydroxide as an efficient and recyclable catalyst system for click chemistry using choline azide as reagent and reaction medium. Catal. Lett. 150, 1186–1195 (2020).

Article CAS Google Scholar

Dolatkhah, Z., Mohammadkhani, A., Javanshir, S. & Bazgir, A. Peanut shell as a green biomolecule support for anchoring Cu2O: a biocatalyst for green synthesis of 1, 2, 3-triazoles under ultrasonic irradiation. BMC Chem. 13, 1–10 (2019).

Article CAS Google Scholar

Download references

Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran

Fatemeh Salehzadeh, Maryam Esmkhani, Mahsa Zallaghi, Shahrzad Javanshir & Mohammad G. Dekamin

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

You can also search for this author in PubMed Google Scholar

F.S.: Performed experiments and data collection/drew figures/ Writing-original draft preparation. M. E.: Conceptualization/ Supervisor/ Writing-original draft preparation /provided the revisions to the content of the manuscript. M. Z.: Provided the revisions to the content of the manuscript. S. J.: Supervisor and head of project/Validation/ Review and Editing. M.G.D.: Advisor.

Correspondence to Shahrzad Javanshir.

The authors declare no competing interests.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

Salehzadeh, F., Esmkhani, M., Zallaghi, M. et al. CuFe2O4@SiO2@L-arginine@Cu(I) as a new magnetically retrievable heterogeneous nanocatalyst with high efficiency for 1,4-disubstituted 1,2,3-triazoles synthesis. Sci Rep 13, 8675 (2023). https://doi.org/10.1038/s41598-023-36012-8

Download citation

Received: 07 August 2022

Accepted: 27 May 2023

Published: 29 May 2023

DOI: https://doi.org/10.1038/s41598-023-36012-8

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.